Nino Kalandadze is an expert in the chemical technology of organic substances, having studied from 1988 to 1993 (qualification: equivalent to a Master's degree), and a technical expert in antiquities, from 1993 to 2000 (Master's degree). Since 1997, she has been a member of the Georgian Academy of Sciences, Archaeological Research Center (1997 - laboratory assistant, 2000 - junior research fellow, 2006 - senior research fellow). She was awarded a scientific degree in 2006 (Topic: Typological and technological study of Colchian Late Bronze-Early Iron Age engraved and incrusted bronze artifacts).

Since 2008, she has continued her professional activities at the Georgian National Museum, initially as the head of the Collections Management Department and since 2017, as the head of the Restoration and Conservation Research Institute. Nino Kalandadze has participated in numerous rehabilitation projects for permanent and temporary exhibitions at the Georgian National Museum, as well as regional museums (Svaneti, Akhaltsikhe, Bolnisi, and Vani archaeological museums). From 2009 to 2012, she led two components of the Council of Europe-supported "twinning" project. In 2007, she was a fellow at the Conservation Institute of the Smithsonian Institution in Washington, D.C.; in 2008, she was invited as a conservator at The Metropolitan Museum of Art in New York; and in 2009, she was an invited conservator at The Getty Villa Museum in Los Angeles, USA.

Nino Kalandadze was a scholarship holder at the Roman-Germanic Central Museum in Mainz, Germany, in 2000, 2001, and 2003. She has been engaged in scientific work for many years, focusing on the study and conservation of ancient organic and inorganic artifacts. She is the author and co-author of 24 scientific articles and 5 monographs.

Nino Kalandadze also teaches at Tbilisi State University and the Georgian Technical University.